Description

Brexpiprazole n-Oxide is a key pharmaceutical intermediate and metabolite of the antipsychotic drug Brexpiprazole. This compound is of significant importance for research and development, particularly in the areas of drug metabolism studies, pharmacokinetic analysis, and the synthesis of related active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories, analytical service providers, and manufacturers engaged in the production of high-purity reference standards and novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and qualification of Brexpiprazole and its metabolites in analytical methods.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic pathways, bioavailability, and excretion profiles of Brexpiprazole in preclinical and clinical research.
• Impurity Profiling: Serves as a critical impurity standard in the quality control of Brexpiprazole active pharmaceutical ingredient (API) to ensure product safety and compliance with ICH guidelines.
• Organic Synthesis Intermediate: Employed in the research-scale synthesis of novel Brexpiprazole analogs and derivatives for medicinal chemistry programs.
• Analytical Method Development: Used to develop and validate sensitive HPLC, LC-MS, and GC-MS methods for the detection of Brexpiprazole-related compounds.

Basic Information

Product Name	Brexpiprazole n-Oxide
CAS No.	1191900-58-9
Molecular Formula	C₂₅H₂₇N₃O₃S
Molecular Weight	449.57 g/mol
Synonyms	7-{4-[4-(1-Benzothiophen-4-yl)piperazin-1-yl]butoxy}-1,2,3,4-tetrahydroquinolin-2-one 1-Oxide; Brexpiprazole N-Oxide; Brexpiprazole Metabolite; Rexulti Metabolite; UNII-8V6T7Q8Q8S; 1,2,3,4-Tetrahydro-7-[4-[4-(4-benzothienyl)-1-piperazinyl]butoxy]-2-oxoquinoline 1-oxide; 4-(4-(4-(Benzo[b]thiophen-4-yl)piperazin-1-yl)butoxy)-3,4-dihydroquinolin-2(1H)-one 1-oxide
EINECS	Contact for details

Quality Control

Our Brexpiprazole n-Oxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical research materials. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles by validated methods (e.g., HPLC, NMR) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.