Description

Cyclobutanepropanoic Acid, 3,3-Difluoro-β-Oxo-, Methyl Ester is a high-purity, specialized fluorinated organic building block of significant interest in advanced synthetic chemistry. Its core value lies in its unique molecular architecture, featuring a cyclobutane ring and a β-keto ester motif, which makes it a versatile precursor for constructing complex, fluorinated target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to introduce fluorinated cyclobutyl groups to modulate the biological activity, metabolic stability, and physicochemical properties of new chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, where the fluorinated cyclobutane moiety can enhance lipophilicity and environmental stability.
• Fluorine Chemistry & Material Science: Serves as a valuable building block for creating fluorinated polymers, liquid crystals, or organic electronic materials with tailored properties.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development and exploring new reaction pathways in organofluorine chemistry.
• Custom Synthesis & Scale-Up: A critical starting material for custom synthesis providers offering contract manufacturing services for preclinical and early-phase clinical trial materials.

Basic Information

Product Name	Cyclobutanepropanoic Acid, 3,3-Difluoro-β-Oxo-, Methyl Ester
CAS No.	1191096-28-2
Molecular Formula	C8H10F2O3
Molecular Weight	192.16 g/mol
Synonyms	Methyl 3,3-difluoro-2-oxocyclobutanepropanoate; 3,3-Difluoro-2-oxocyclobutanepropanoic Acid Methyl Ester; Methyl 3,3-Difluoro-β-oxocyclobutanepropanoate; 2-Oxocyclobutanepropanoic Acid, 3,3-Difluoro-, Methyl Ester; Cyclobutanepropanoic Acid, 3,3-Difluoro-2-Oxo-, Methyl Ester; Difluorinated Cyclobutyl β-Keto Ester
EINECS	Contact for details

Quality Control

Our Cyclobutanepropanoic Acid, 3,3-Difluoro-β-Oxo-, Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring consistency and reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.