Description

Fmoc-Nh-Peg9-Ch2Ch2Cooh is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative designed for advanced bioconjugation and linker applications. This compound matters for its precise functionality, featuring an amine-reactive Fmoc-protected group and a carboxylic acid terminus, enabling controlled, sequential synthesis of complex biomolecules. It is primarily needed by researchers and manufacturers in the pharmaceutical and biotechnology industries for developing novel drug delivery systems, peptide therapeutics, and diagnostic reagents.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a hydrophilic, flexible spacer to improve the solubility and bioavailability of synthetic peptides.
• Bioconjugation and Linker Chemistry: Used to create stable linkages between drugs, proteins, antibodies, and other biomolecules or surfaces.
• ADC (Antibody-Drug Conjugate) Development: Functions as a crucial component in the linker-payload construct to enhance therapeutic index and stability.
• PEGylation: Acts as a PEGylation reagent to modify therapeutic proteins, reducing immunogenicity and extending plasma half-life.
• Diagnostic Probe Synthesis: Utilized in the construction of fluorescent or radioactive probes for imaging and diagnostic assays.
• Material Science & Surface Modification: Applied to functionalize nanoparticles, biosensors, and other materials with specific bioactive groups.
• Cross-linking Agent: Employed to create three-dimensional networks in hydrogel formation for tissue engineering and controlled release.

Basic Information

Product Name	Fmoc-Nh-Peg9-Ch2Ch2Cooh
CAS No.	1191064-81-9
Molecular Formula	C₅₈H₉₅N₃O₂₄
Molecular Weight	1206.4 g/mol
Synonyms	Fmoc-NH-PEG9-COOH; Fmoc-N-amido-PEG9-acid; 2-[2-[2-[2-[2-[2-[2-[2-[2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic Acid; Fmoc-8-amino-3,6-dioxaoctanoic Acid-PEG7-acid; Fmoc-NH-(PEG)9-COOH; Fmoc-AEEA-PEG9-acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3,6,9,12,15,18,21,24,27-nonaoxa-30-azatriacontan-30-oic Acid; Fmoc-PEG9-acid
EINECS	Contact for details

Quality Control

Our Fmoc-Nh-Peg9-Ch2Ch2Cooh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and cGMP applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity, purity, and absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to warm to room temperature before opening to minimize moisture condensation. For long-term storage, keep under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.