Description

1-Bromo-4-Ethynyl-2-Fluorobenzene is a high-value, multi-functional aromatic building block featuring bromine, fluorine, and an ethynyl group. This unique combination of halogens and an alkyne moiety makes it a critical intermediate for constructing complex molecular architectures via cross-coupling and click chemistry reactions. It is primarily sought after by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the development of new active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly in oncology and CNS research.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Material Science: Serves as a monomer or cross-linker in the production of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research: An essential reagent for Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions in organic synthesis.
• Fluorine Chemistry: Utilized in the study of fluorinated compounds and their unique physicochemical properties.
• Ligand and Catalyst Development: Acts as a precursor for creating sophisticated ligands used in asymmetric catalysis.

Basic Information

Product Name	1-Bromo-4-Ethynyl-2-Fluorobenzene
CAS No.	1191063-07-6
Molecular Formula	C8H4BrF
Molecular Weight	199.02 g/mol
Synonyms	4-Bromo-3-fluoroethynylbenzene; 2-Fluoro-4-bromoethynylbenzene; 1-Bromo-4-ethynyl-2-fluorobenzene; 4-Ethynyl-1-bromo-2-fluorobenzene; 2-Fluoro-4-bromophenylacetylene; (4-Bromo-3-fluorophenyl)acetylene; 3-Fluoro-4-bromophenylacetylene
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-Ethynyl-2-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.