Description

4-Fluorophenylboronic Acid n-Butyldiethanolamine Ester is a specialized organoboron reagent designed to enhance stability and handling characteristics for advanced synthetic applications. This compound is a protected boronic acid derivative, offering improved shelf-life and reduced sensitivity to moisture compared to its free acid counterpart, which is critical for reliable performance in multi-step syntheses. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl scaffolds.

Application

• Pharmaceutical Intermediate Synthesis: Key building block for creating fluorinated active pharmaceutical ingredients (APIs) and drug candidates via palladium-catalyzed cross-coupling.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides containing fluorinated aromatic systems.
• Material Science: Precursor for synthesizing fluorinated organic electronic materials, such as ligands for OLEDs and semiconductors.
• Chemical Biology & Proteomics: Employed in the synthesis of fluorinated probes, tags, and inhibitors for studying biological systems.
• Process Chemistry & Scale-up: The ester form provides superior handling and stability for large-scale manufacturing processes compared to sensitive boronic acids.
• Academic & Contract Research: Essential reagent for methodological development and complex molecule construction in academic and industrial R&D laboratories.

Basic Information

Product Name	4-Fluorophenylboronic Acid n-Butyldiethanolamine Ester
CAS No.	1190988-96-5
Molecular Formula	C₁₄H₂₁BFNO₂
Molecular Weight	265.13 g/mol
Synonyms	4-Fluorophenylboronic Acid N,N-Diethanol-n-butylamine Ester; n-Butyldiethanolamine 4-Fluorophenylboronate; B-(4-Fluorophenyl)-N,N-bis(2-hydroxyethyl)-N-butylborinic Acid Amine Ester; 4-Fluorobenzeneboronic Acid n-Butyldiethanolamine Ester; 4-Fluorophenylboronic Acid Diethanol-n-butylamine Ester; 4-Fluorophenyl-Boron, Complex with N,N-Bis(2-hydroxyethyl)-N-butylamine; (4-Fluorophenyl)boronic Acid n-Butyldiethanolamine Ester
EINECS	Contact for details

Quality Control

Our 4-Fluorophenylboronic Acid n-Butyldiethanolamine Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (¹H, ¹³C, ¹¹B), HPLC, and Karl Fischer titration, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF Titration)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.