Description

Tricyclohexylphosphine[2,4-Dihydro-2,4,5-Triphenyl-3H-1,2,4-Triazol-3-Ylidene][2-Thienylmethylene]Ruthenium(Ii) Dichloride, Min. 95% is a highly specialized, second-generation Grubbs-Hoveyda type ruthenium-based olefin metathesis catalyst. This compound is engineered for superior performance in demanding synthetic applications, offering enhanced stability and reactivity profiles. It is a critical reagent for researchers and process chemists in pharmaceutical development, advanced materials science, and specialty chemical synthesis, where precise control over carbon-carbon double bond formation is required.

Application

• Pharmaceutical Intermediate Synthesis: Enabling key ring-closing metathesis (RCM), cross metathesis (CM), and ring-opening metathesis polymerization (ROMP) steps in the production of active pharmaceutical ingredients (APIs) and complex natural products.
• Advanced Polymer & Material Science: Facilitating the synthesis of tailored polymers, functionalized surfaces, and novel materials with specific mechanical or chemical properties via ROMP and CM reactions.
• Specialty & Fine Chemical Manufacturing: Used in the scalable production of fragrances, agrochemicals, and other high-value fine chemicals requiring efficient olefin metathesis transformations.
• Academic & Industrial R&D: Serving as a premium catalyst for method development and exploration of new synthetic pathways in organic and organometallic chemistry.
• Macrocycle Synthesis: Particularly effective for the challenging construction of medium and large rings, which are common structural motifs in many bioactive molecules.

Basic Information

Product Name	Tricyclohexylphosphine[2,4-Dihydro-2,4,5-Triphenyl-3H-1,2,4-Triazol-3-Ylidene][2-Thienylmethylene]Ruthenium(Ii) Dichloride, Min. 95%
CAS No.	1190427-51-0
Molecular Formula	C46H52Cl2N3PRuS
Molecular Weight	889.92 g/mol
Synonyms	Grubbs-Hoveyda II Catalyst; Hoveyda-Grubbs Catalyst 2nd Generation; (1,3-Bis-(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(o-isopropoxyphenylmethylene)ruthenium; Dichloro[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene](2-thienylmethylene)(tricyclohexylphosphine)ruthenium(II); Ru Catalyst (Grubbs II type); Zhan Catalyst 1B; [RuCl2(IMesH2)(=CH-2-Thienyl)(PCy3)]
EINECS	Contact for details

Quality Control

Our ruthenium metathesis catalysts are produced and handled under strict inert atmosphere conditions to ensure maximum activity and shelf-life. Every batch undergoes comprehensive analytical characterization, including NMR, HPLC, and elemental analysis, to verify identity, purity, and conformity to specifications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting the critical quality attributes for traceability and assurance.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C. The product is sensitive to moisture and oxygen; allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation.

Specification

Item	Specification
Appearance	Purple to brown crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	Min. 95%
Solubility	Soluble in common organic solvents (DCM, toluene, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.