Description

2-(2-Fluoro-5-Methoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its value lies in enabling efficient carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to introduce the 2-fluoro-5-methoxyphenyl moiety into target molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific aryl-fluorine substitution patterns.
• Material Science Research: Employed in the development of organic light-emitting diodes (OLEDs), liquid crystals, and other functional organic materials.
• Cross-Coupling Reactions: A specialized reagent for Suzuki-Miyaura cross-coupling, enabling the efficient and selective formation of biaryl and heterobiaryl structures.
• Chemical Biology & Proteomics: Serves as a versatile handle for bioconjugation and the synthesis of molecular probes for target identification and validation.
• Academic & Contract Research: A valuable tool for synthetic methodology development and complex molecule construction in academic and industrial R&D laboratories.

Basic Information

Product Name	2-(2-Fluoro-5-Methoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1190129-83-9
Molecular Formula	C13H18BFO3
Molecular Weight	252.09 g/mol
Synonyms	2-Fluoro-5-methoxyphenylboronic acid pinacol ester; (2-Fluoro-5-methoxyphenyl)boronic acid pinacol ester; 2-Fluoro-5-methoxybenzeneboronic acid pinacol ester; Pinacol (2-fluoro-5-methoxyphenyl)boronate; 2-(2-Fluoro-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1190129-83-9; 2-Fluoro-5-methoxybenzeneboronic acid, pinacol ester; 5-Methoxy-2-fluorophenylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-(2-Fluoro-5-Methoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring reproducible results in sensitive synthetic processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and easily oxidized; for long-term storage, it is recommended to keep the container under an inert atmosphere (argon or nitrogen). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.