Description

2-(5-Chloro-2-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic chemistry. Its value lies in enabling efficient and selective carbon-carbon bond formation, specifically through the Suzuki-Miyaura cross-coupling reaction, which is fundamental to pharmaceutical and advanced materials research. This compound is essential for R&D chemists and process development scientists working in pharmaceutical, agrochemical, and organic electronics industries who require reliable, high-quality intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing biaryl motifs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides requiring specific halogenated phenyl structures.
• Material Science: Building block for creating organic light-emitting diodes (OLEDs), liquid crystals, and conductive polymers.
• Chemical Research & Development: A versatile reagent for method development, library synthesis, and exploring new catalytic processes in academic and industrial labs.
• Suzuki-Miyaura Cross-Coupling Reactions: The primary application, facilitating the coupling of the chloro-fluorophenyl moiety with various aryl or vinyl halides in the presence of a palladium catalyst.
• Ligand and Catalyst Preparation: Can be utilized to synthesize novel bidentate or monodentate ligands for transition metal catalysis.

Basic Information

Product Name	2-(5-Chloro-2-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1190129-77-1
Molecular Formula	C12H15BClFO2
Molecular Weight	255.51 g/mol
Synonyms	5-Chloro-2-fluorophenylboronic acid pinacol ester; (5-Chloro-2-fluorophenyl)boronic acid pinacol ester; 2-(5-Chloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Chloro-2-fluoro-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene; 1-Chloro-4-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene; 2-Fluoro-5-chlorophenylboronic acid pinacol ester; Pinacol (5-chloro-2-fluorophenyl)boronate
EINECS	Contact for details

Quality Control

Our 2-(5-Chloro-2-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high purity and lot-to-lot consistency suitable for sensitive cross-coupling applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability and to minimize hydrolysis. Recommended storage temperature is 2-8°C for extended periods, though short-term storage at 15-25°C is acceptable if the container remains sealed.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.