Description

Lercanidipine-D3 CAS NO 1190043-34-5 is a deuterated isotopologue of the calcium channel blocker Lercanidipine, where three hydrogen atoms are replaced by deuterium. This high-purity stable-labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical material for pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers engaged in the development and quality control of cardiovascular drugs.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) analysis of Lercanidipine in biological matrices (plasma, serum, urine).
• Drug Metabolism and Pharmacokinetics (DMPK): Enables precise tracking of the parent drug's absorption, distribution, metabolism, and excretion (ADME) profile in preclinical and clinical studies.
• Bioequivalence Studies: Critical for ensuring analytical method accuracy in studies comparing generic and innovator drug formulations.
• Pharmaceutical Impurity Profiling: Used in method development to identify and quantify potential deuterated impurities or related substances in active pharmaceutical ingredient (API) batches.
• Forensic and Clinical Toxicology: Supports accurate quantification of Lercanidipine in cases of overdose or therapeutic drug monitoring.

Basic Information

Product Name	Lercanidipine-D3
CAS No.	1190043-34-5
Molecular Formula	C36H38D3N2O6
Molecular Weight	612.75 g/mol (approximate)
Synonyms	Lercanidipine-d3; (2S)-1,1-Dimethylethyl 2-[(3S)-1,1-Di(1,1-dimethylethyl)-3-(3,3-diphenylpropyl)-2,4-dioxo-6-(2,3,4-trimethoxyphenyl)-1,2,3,4-tetrahydro-5-pyrimidinyl]ethyl methyl carbonate-d3; Lercanidipine (phenyl-d3); Lercanidipine Internal Standard; Lercanidipine Stable Labeled Isotope; Lercanidipine-D3 Isotopologue; Deuterated Lercanidipine
EINECS	Contact for details

Quality Control

Our Lercanidipine-D3 is manufactured under strict quality control protocols to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (HPLC), isotopic purity (deuterium incorporation), and residual solvents. We support compliance with cGMP and ICH Q7 guidelines for APIs used in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to expected mass
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 99.0 atom % D
Chemical Purity (by HPLC)	≥ 98.0%
Residual Solvents (GC)	Complies with ICH limits
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.