Description

Alosetron D3 is a deuterated analog of Alosetron, a selective 5-HT3 receptor antagonist, where specific hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is essential for high-precision analytical research, serving as a critical internal standard in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical chemists requiring definitive quantification in complex biological matrices.

Application

• Internal Standard for LC-MS/MS: Serves as a quantitative reference standard in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) bioanalysis for drug development.
• Pharmacokinetic Studies: Enables accurate tracking and measurement of Alosetron absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Metabolite Identification: Used in mass spectrometry to differentiate drug-derived metabolites from endogenous compounds, aiding in metabolic pathway elucidation.
• Bioanalytical Method Development: Critical for validating sensitive and specific analytical methods in compliance with FDA and ICH guidelines.
• Drug-Drug Interaction Studies: Supports research into how Alosetron interacts with other co-administered pharmaceuticals.
• Stable Isotope Dilution Assay (SIDA): Provides the highest accuracy in quantitative analysis by correcting for sample preparation and instrument variability.

Basic Information

Product Name	Alosetron D3
CAS No.	1190043-13-0
Molecular Formula	C17H15D3N4O
Molecular Weight	295.36 g/mol
Synonyms	Alosetron-d3; Deuterated Alosetron; 2,3,4,5-Tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one-d3; Lotronex-d3; GR 68755C-d3; (5-Methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one)-d3
EINECS	Contact for details

Quality Control

Every batch of Alosetron D3 is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity suitable for the most demanding analytical applications. Comprehensive testing includes identity confirmation, assay, isotopic enrichment (D3), and control of related substances and residual solvents. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.