Description

Naratriptan-D3 Hydrochloride is a deuterium-labeled internal standard of the selective serotonin receptor agonist, Naratriptan. This high-purity compound is essential for ensuring the accuracy and reliability of quantitative bioanalytical methods, particularly in pharmacokinetic and metabolism studies. It is a critical material for pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical service providers focused on the development and quality control of triptan-class migraine therapeutics.

Application

• Primary use as an Internal Standard (IS) in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and Gas Chromatography-Mass Spectrometry (GC-MS) bioanalysis.
• Quantification of Naratriptan in biological matrices (e.g., plasma, serum, urine) for pharmacokinetic (PK) and bioavailability studies.
• Metabolite identification and profiling in drug metabolism and pharmacokinetics (DMPK) research.
• Method development and validation in accordance with FDA, EMA, and ICH regulatory guidelines.
• Quality control and assurance testing for active pharmaceutical ingredient (API) manufacturers.
• Use in clinical research to monitor drug levels and ensure patient safety during trials.

Basic Information

Product Name	Naratriptan-D3 Hydrochloride
CAS No.	1190021-64-7
Molecular Formula	C17H22D3N3O2S•HCl
Molecular Weight	371.94 g/mol (approx.)
Synonyms	N-Methyl-3-(1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide-d3 Hydrochloride; 1-[3-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide-d3 Hydrochloride; Naratriptan-d3 HCl; NAR-d3 HCl; Deuterated Naratriptan Hydrochloride; (R)-Naratriptan-d3 Hydrochloride; N-Methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonamide-d3 Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Naratriptan-D3 Hydrochloride is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, confirmed by advanced analytical techniques including NMR, HPLC, and Mass Spectrometry. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific results for identity, purity (HPLC), isotopic enrichment, and residual solvents. Our quality commitment supports compliance with cGMP and ICH Q7 guidelines for pharmaceutical reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium Enrichment)	≥98 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.