Description

Zolpidem-D6 6-Carboxylic Acid is a high-purity, stable isotope-labeled derivative of zolpidem, specifically designed for use as an internal standard in quantitative analytical methods. This compound is critical for ensuring accuracy and reliability in mass spectrometry-based assays, particularly in regulated environments. It is an essential tool for pharmaceutical research, forensic toxicology, and clinical laboratories conducting pharmacokinetic studies and drug metabolism research.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard for the precise analysis of zolpidem and its metabolites in biological matrices.
• Pharmaceutical R&D: Used in drug metabolism and pharmacokinetics (DMPK) studies to track and quantify the parent drug and its degradation pathways.
• Forensic Toxicology: Enables accurate quantification of zolpidem in post-mortem and human performance testing, supporting legal and medical investigations.
• Clinical Research: Facilitates therapeutic drug monitoring (TDM) and bioequivalence studies for generic drug development.
• Reference Standard: Serves as a certified reference material (CRM) for method development, validation, and laboratory quality control procedures.
• Metabolite Synthesis: Acts as a key synthetic intermediate for the preparation of deuterium-labeled metabolites of zolpidem.

Basic Information

Item	Details
Product Name	Zolpidem-D6 6-Carboxylic Acid
CAS No.	1190014-62-0
Molecular Formula	C19H15D6N3O3
Molecular Weight	333.39 g/mol
Synonyms	Zolpidem-2H6 6-Carboxylic Acid; 6-Carboxyzolpidem-D6; N,N-Dimethyl-2-(6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl)acetamide-D6 6-Carboxylic Acid; Deuterated Zolpidem Acid; Zolpidem-D6 Acid Metabolite; [2H6]-Zolpidem-6-carboxylic Acid; Zolpidem (phenyl-D5, methyl-D) 6-Carboxylic Acid
EINECS	Contact for details

Quality Control

Every batch of Zolpidem-D6 6-Carboxylic Acid is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We guarantee high chemical and isotopic purity to meet the exacting requirements of analytical reference standards. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results for identity, assay, isotopic enrichment, and impurity profile via techniques such as NMR, HPLC, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, keep under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.