Description

Citalopram-D6 HBr is a deuterated internal standard of the widely prescribed antidepressant, Citalopram. This high-purity, isotopically labeled compound is essential for ensuring the accuracy and reliability of quantitative analytical methods. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities for applications requiring precise measurement and validation.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard in LC-MS/MS and GC-MS methods for the precise quantification of Citalopram and its metabolites in biological matrices (plasma, serum, urine).
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion in clinical and preclinical research.
• Drug Metabolism and Disposition Studies: Used to differentiate between administered drug and endogenous compounds or metabolites during ADME profiling.
• Forensic and Clinical Toxicology: Supports accurate assay development for therapeutic drug monitoring (TDM) and forensic analysis.
• Method Development and Validation: A key reagent for developing, optimizing, and validating robust analytical methods in compliance with ICH, FDA, and EMA guidelines.
• Quality Control in Pharmaceutical Manufacturing: Can be utilized in impurity profiling and stability-indicating assay methods for drug substance and product quality assurance.

Basic Information

Product Name	Citalopram-D6 HBr
CAS No.	1190003-26-9
Molecular Formula	C20H15D6FN2O•HBr
Molecular Weight	411.33 g/mol
Synonyms	1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-(D3-methyl)-2-benzofuran-D3-carbonitrile Hydrobromide; Citalopram-d6 Hydrobromide; (RS)-Citalopram-d6 HBr; 1-(3-Dimethylaminopropyl)-1-(4-fluorophenyl)-5-(D3-methyl)isobenzofuran-D3-carbonitrile Hydrobromide; Deuterated Citalopram HBr Internal Standard
EINECS	Contact for details

Quality Control

Our Citalopram-D6 HBr is manufactured under strict quality control protocols to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as assay (by HPLC), isotopic enrichment (by MS), and impurity profile. We adhere to relevant industry standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.