Description

n-Deshydroxyethyl Dasatinib-D8 is a deuterated analog of a key pharmaceutical intermediate, specifically designed for advanced research and development applications. This high-purity compound is essential for conducting precise metabolic, pharmacokinetic, and bioanalytical studies, providing critical data for drug development programs. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on oncology and kinase inhibitor research.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, stable isotope-labeled internal standard in quantitative bioanalysis for accurate measurement of Dasatinib and related metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used in tracing and quantifying metabolic pathways, absorption, distribution, and excretion profiles in preclinical and clinical research.
• Pharmaceutical Impurity Profiling: Acts as a reference standard for the identification and quantification of process-related impurities and degradation products in active pharmaceutical ingredient (API) manufacturing.
• Stable Isotope Labeling Research: Employed in mechanistic studies to understand drug-receptor interactions and the fate of molecules in biological systems.
• Method Development and Validation: Essential for developing and validating robust analytical methods in compliance with regulatory guidelines (e.g., FDA, ICH).

Basic Information

Product Name	n-Deshydroxyethyl Dasatinib-D8
CAS No.	1189998-96-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Dasatinib D8 Derivative; Dasatinib-d8 Deshydroxyethyl Analog; N-Deshydroxyethyl Dasatinib Deuterated; BMS-354825 D8 Derivative; Deuterated Dasatinib Intermediate; [D8]-n-Deshydroxyethyl Dasatinib; Stable Isotope Labeled Dasatinib Metabolite Standard
EINECS	Contact for details

Quality Control

Our n-Deshydroxyethyl Dasatinib-D8 is manufactured under strict quality control protocols to ensure the highest standards of purity and isotopic enrichment required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC), isotopic purity (D-content), and identity confirmation (by NMR and MS). We adhere to relevant industry standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.