Description

4-Hydroxy Clonidine-D4 is a stable isotope-labeled analog of the 4-hydroxy metabolite of the antihypertensive agent clonidine. This deuterated compound is essential as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical researchers, clinical laboratories, and contract research organizations (CROs) engaged in drug development and therapeutic drug monitoring.

Application

• Bioanalytical Internal Standard: Primary use as a reference standard in LC-MS/MS and GC-MS assays for the quantification of 4-hydroxy clonidine in biological matrices (plasma, serum, urine).
• Drug Metabolism and Pharmacokinetics (DMPK): Enables precise tracking of the metabolic fate and clearance rates of clonidine in preclinical and clinical studies.
• Clinical Research: Supports studies investigating individual patient response, drug-drug interactions, and adherence monitoring for clonidine therapy.
• Forensic Toxicology: Used in confirmatory testing for clonidine and its metabolites in forensic and workplace drug testing scenarios.
• Pharmaceutical Quality Control: Applicable in the development and validation of analytical methods for impurity profiling and stability testing of clonidine-based formulations.

Basic Information

Product Name	4-Hydroxy Clonidine-D4
CAS No.	1189988-05-3
Molecular Formula	C9H5D4Cl2N3O
Molecular Weight	234.12 g/mol (for deuterated form)
Synonyms	2,6-Dichloro-N-(2-imidazolidinylidene)-4-hydroxybenzenamine-D4; 4-Hydroxy-2,6-dichlorophenylaminoimidazoline-D4; Clonidine 4-hydroxy metabolite D4; Clonidine 4-OH metabolite-d4; Deuterated 4-Hydroxyclonidine; [2H4]-4-Hydroxyclonidine; 4-OH-Clonidine-d4
EINECS	Contact for details

Quality Control

Every batch of 4-Hydroxy Clonidine-D4 is manufactured and analyzed under strict quality systems. We provide comprehensive analytical data to support your regulatory submissions, including Certificates of Analysis (COA) with detailed results for identity, purity (HPLC), isotopic enrichment (NMR/MS), and chemical purity. Our quality commitment ensures consistency and traceability for critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment. For long-term storage, consider storing under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.