Description

Haloperidol-D4 is a deuterium-labeled analog of the antipsychotic drug Haloperidol, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity reference material is essential for ensuring accuracy and reliability in mass spectrometry-based analyses, such as LC-MS/MS. It is primarily used by pharmaceutical researchers, clinical laboratories, and forensic toxicologists for precise drug metabolism and pharmacokinetic (DMPK) studies, therapeutic drug monitoring, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS Analysis: Critical for achieving accurate quantification of Haloperidol and its metabolites in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in research to study the absorption, distribution, metabolism, and excretion (ADME) profile of Haloperidol.
• Therapeutic Drug Monitoring (TDM): Enables precise measurement of Haloperidol concentrations in patient samples to optimize dosing and minimize side effects.
• Forensic and Clinical Toxicology: Supports the accurate identification and quantification of Haloperidol in cases of overdose or compliance testing.
• Bioanalytical Method Development and Validation: Serves as a key component in developing robust, sensitive, and reproducible analytical assays.
• Pharmaceutical Quality Control: Can be utilized in impurity profiling and stability studies of Haloperidol drug substances and products.

Basic Information

Product Name	Haloperidol-D4
CAS No.	1189986-59-1
Molecular Formula	C21H19D4ClFNO2
Molecular Weight	379.88 g/mol (deuterated form)
Synonyms	4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone-d4; Haloperidol (phenyl-d4); 1-(4-Fluorophenyl-d4)-4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]butan-1-one; Haloperidol-d4 Internal Standard; Deuterated Haloperidol
EINECS	Contact for details

Quality Control

Our Haloperidol-D4 is manufactured under strict quality systems to ensure the highest standards of purity and isotopic enrichment, critical for its role as an analytical reference standard. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for chemical purity, isotopic purity (D-enrichment), and identity confirmation. We support research and compliance needs in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.