Description

2-Keto-3-(Methyl-D3)-Butyric Acid-4-13C Sodium Salt is a high-purity, isotopically labeled compound designed for advanced research and analytical applications. This material serves as a critical stable isotope-labeled intermediate and internal standard, enabling precise metabolic pathway tracing and quantitative analysis in complex biological systems. It is essential for researchers and manufacturers in pharmaceutical development, clinical diagnostics, and metabolic research requiring the highest levels of accuracy and reliability.

Application

• Internal Standard for Mass Spectrometry (MS): Used as a quantitative reference standard in LC-MS and GC-MS analysis for accurate measurement of metabolites and related compounds.
• Metabolic Pathway Tracing: Employed in 13C and deuterium (2H) tracer studies to investigate biochemical pathways, including amino acid and ketone body metabolism.
• Pharmaceutical Impurity Profiling: Critical for the identification and quantification of process-related impurities and degradation products in active pharmaceutical ingredient (API) development.
• Clinical Diagnostic Assays: Incorporated into high-sensitivity diagnostic kits for the accurate detection of specific biomarkers in patient samples.
• Biochemical Research: Serves as a labeled precursor or intermediate in enzymatic studies and the synthesis of more complex isotopically labeled molecules.
• Nutrient Metabolism Studies: Applied in nutritional science research to track the utilization and fate of specific nutrients within biological systems.

Basic Information

Product Name	2-Keto-3-(Methyl-D3)-Butyric Acid-4-13C Sodium Salt
CAS No.	1189985-32-7
Molecular Formula	C4H2D313NaO3
Molecular Weight	Contact for details
Synonyms	3-Methyl-2-oxobutanoic-4-13C-3-(methyl-d3) acid sodium salt; Sodium 2-oxo-3-(trideuteriomethyl)-4-13C-butanoate; α-Ketoisovaleric-4-13C-3-(methyl-d3) acid sodium salt; Sodium 2-keto-3-(methyl-d3)-4-13C-butyrate; KIV-13C,d3 sodium salt; 2-Oxoisovaleric-4-13C-3-(methyl-d3) acid sodium salt; Isotopically labeled α-ketoisovalerate sodium salt.
EINECS	Contact for details

Quality Control

Every batch of 2-Keto-3-(Methyl-D3)-Butyric Acid-4-13C Sodium Salt is manufactured and tested under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, supported by comprehensive analytical data including NMR, MS, and HPLC. A Certificate of Analysis (COA) detailing purity, isotopic purity (enrichment), and specific tests is provided with each shipment to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment. For long-term stability, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (13C)	≥ 99 atom % 13C
Isotopic Purity (D)	≥ 98 atom % D
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.