Description

D,L-n-Desmethylvenlafaxine-D3 is a deuterium-labeled internal standard of a key venlafaxine metabolite, specifically designed for high-precision analytical applications. This compound is essential for ensuring accurate quantification and method validation in bioanalytical studies, providing superior reliability in complex matrices. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and forensic toxicology units engaged in pharmacokinetic research, therapeutic drug monitoring, and metabolite profiling.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard for the accurate LC-MS/MS quantification of O-desmethylvenlafaxine (ODV) in biological samples such as plasma, serum, and urine.
• Pharmacokinetic & Metabolism Studies: Enables precise tracking of venlafaxine and its primary active metabolite for ADME (Absorption, Distribution, Metabolism, Excretion) profiling in clinical and preclinical research.
• Therapeutic Drug Monitoring (TDM): Used in developing and validating robust assays to monitor patient drug levels, optimizing dosage regimens for antidepressants.
• Forensic Toxicology: Aids in the definitive identification and quantification of venlafaxine and its metabolites in forensic investigations and compliance testing.
• Method Development & Validation: Provides a stable, isotopically-labeled reference for developing new analytical methods, ensuring specificity, accuracy, and reproducibility.
• Quality Control in Reference Material Production: Employed as a calibrant or system suitability standard in the manufacturing of certified reference materials (CRMs).

Basic Information

Product Name	D,L-n-Desmethylvenlafaxine-D3
CAS No.	1189980-40-2
Molecular Formula	C16H22D3NO2
Molecular Weight	266.40 g/mol
Synonyms	O-Desmethylvenlafaxine-d3; O-Demethylvenlafaxine-d3; ODV-d3; (R/S)-1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol-d3; Desvenlafaxine Impurity D3; Venlafaxine Metabolite O-desmethyl-d3; 1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol (deuterated); 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol-d3
EINECS	Contact for details

Quality Control

Every batch of D,L-n-Desmethylvenlafaxine-D3 is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We guarantee high chemical and isotopic purity, confirmed by advanced techniques including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic enrichment, and solvent content to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.