Description

Rac Quinacrine-D10 is a deuterium-labeled analog of the antimalarial and anti-inflammatory compound quinacrine. This stable isotope-labeled internal standard is critical for ensuring accuracy and reliability in quantitative analytical methods, particularly liquid chromatography-mass spectrometry (LC-MS). It is primarily utilized by pharmaceutical research laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and clinical research.

Application

• Internal Standard for Quantitative LC-MS/MS Analysis: Essential for the precise quantification of quinacrine and its metabolites in complex biological matrices such as plasma, serum, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to track absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Serves as a critical reference compound to establish specificity, accuracy, and precision in analytical assays.
• Clinical Research and Therapeutic Drug Monitoring (TDM): Supports studies investigating drug efficacy, safety, and optimal dosing regimens.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-accuracy measurement techniques to minimize matrix effects and ionization variability.
• Pharmacological Research: Aids in mechanistic studies exploring quinacrine's potential repurposing for other therapeutic areas, such as oncology or virology.

Basic Information

Product Name	Rac Quinacrine-D10
CAS No.	1189976-99-5
Molecular Formula	C23H20D10ClN3O
Molecular Weight	~401.98 g/mol
Synonyms	Quinacrine-d10; 6-Chloro-9-[(4-diethylamino-1-methylbutyl)amino]-2-methoxyacridine-d10; Mepacrine-d10; Atebrin-d10; SN 390-d10; (±)-Quinacrine-d10; rac-Quinacrine-d10; Deuterated Quinacrine
EINECS	Contact for details

Quality Control

Every batch of Rac Quinacrine-D10 is manufactured and analyzed under strict quality management protocols. Our products undergo rigorous quality testing to ensure compliance with industry standards for stable isotope-labeled compounds. Key parameters include isotopic purity (D-enrichment), chemical purity, and identity confirmation. Certificates of Analysis (COA) detailing lot-specific results from NMR, HPLC, and MS are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98.0 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.