Description

Dimesna-D8 CAS NO 1189975-43-6 is a deuterated isotopologue of the chemoprotective agent Dimesna (BNP7787), where eight hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is of critical importance for use as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is an essential tool for researchers and quality control laboratories in the pharmaceutical and contract research organization (CRO) sectors who require precise measurement of the parent drug in complex biological matrices.

Application

• Primary use as a stable isotope-labeled internal standard for Liquid Chromatography-Mass Spectrometry (LC-MS/MS) bioanalysis.
• Enabling accurate quantification of Dimesna in pharmacokinetic (PK) and toxicokinetic (TK) studies during drug development.
• Critical for metabolite profiling and identification research to understand drug disposition.
• Supporting clinical trial sample analysis to ensure data integrity for regulatory submissions.
• Used in method development and validation in analytical chemistry laboratories.
• Application in doping control or forensic analysis where precise identification is required.

Basic Information

Product Name	Dimesna-D8
CAS No.	1189975-43-6
Molecular Formula	C4H2D8Na2O6S2
Molecular Weight	236.27 g/mol (for labeled form)
Synonyms	BNP7787-d8; Disodium 2,2'-dithio-bis(ethanesulfonate)-d8; Dimesna Octadeuterated; Disodium 2,2'-dithiobis(ethanesulfonate)-1,1,2,2,1',1',2',2'-d8; Mesna Disulfide-d8; Tavocept-d8; Deuterated Dimesna Internal Standard
EINECS	Contact for details

Quality Control

Our Dimesna-D8 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS, to confirm identity, isotopic enrichment (typically >98 atom % D), and chemical purity (often >95%). Certificates of Analysis (COA) detailing all specifications are provided to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. Handle under an inert atmosphere if prolonged exposure is anticipated during use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Isotopic Purity	≥ 98 atom % D
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.