Description

Mitoxantrone-D8 is a deuterated analog of the anthracenedione antineoplastic agent, Mitoxantrone, specifically labeled with eight deuterium atoms. This stable isotope-labeled compound is essential for advanced analytical and pharmacokinetic studies, providing superior internal standards for mass spectrometry to ensure accurate quantification. It is a critical material for pharmaceutical R&D, clinical research laboratories, and contract research organizations (CROs) focused on oncology drug development and bioanalytical method validation.

Application

• Internal Standard for LC-MS/MS: Serves as a high-purity, non-interfering internal standard for the precise quantification of Mitoxantrone in complex biological matrices like plasma, serum, and tissue homogenates.
• Pharmacokinetic and Metabolite Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Used to develop, optimize, and validate robust, GLP-compliant analytical methods for regulatory submissions.
• Drug Metabolism Research (DMPK): Facilitates detailed studies on metabolic pathways and the identification of metabolites in drug discovery pipelines.
• Quality Control and Reference Standard: Acts as a certified reference material for in-house quality control of Mitoxantrone APIs and finished pharmaceutical products.

Basic Information

Item	Detail
Product Name	Mitoxantrone-D8
CAS No.	1189974-82-0
Molecular Formula	C22H20D8N4O6
Molecular Weight	444.50 g/mol (approx.)
Synonyms	1,4-Dihydroxy-5,8-bis[2-[(2-hydroxyethyl)amino]ethyl]amino-9,10-anthracenedione-d8; Dihydroxyanthracenedione-d8; Novantrone-d8; Mitoxantrone Octadeuterated; Mitoxantrone-d8 Internal Standard; 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione-d8; CL 232315-d8
EINECS	Contact for details

Quality Control

Every batch of Mitoxantrone-D8 is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to support its use in regulated environments, including deuterium enrichment (D%) verification by NMR and chemical and isotopic purity determination by HPLC and LC-MS. Certificates of Analysis (COA) detailing all specifications and test results are supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	Blue to dark blue solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuterium Enrichment (NMR)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 98.0%
Isotopic Purity (by LC-MS)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.