Description

Desethyl Chloroquine-D4 is a stable isotope-labeled analog of a key chloroquine metabolite, specifically designed for analytical and research applications. This high-purity compound is essential for ensuring accuracy and reliability in quantitative mass spectrometry and pharmacokinetic studies. It serves as a critical internal standard for researchers and quality control laboratories in the pharmaceutical, clinical research, and forensic toxicology sectors.

Application

• Internal Standard for LC-MS/MS quantification of chloroquine and its metabolites in biological matrices (plasma, urine, tissue).
• Reference material for drug metabolism and pharmacokinetic (DMPK) studies in pharmaceutical R&D.
• Calibration standard in forensic and clinical toxicology analysis.
• Use in bioanalytical method development and validation for antimalarial drug research.
• Critical component in doping control analysis for sports anti-doping laboratories.
• Tracer compound in mechanistic studies of chloroquine's action and resistance.

Basic Information

Product Name	Desethyl Chloroquine-D4
CAS No.	1189971-72-9
Molecular Formula	C₁₆H₂₂D₄ClN₃
Molecular Weight	291.86 g/mol (approx.)
Synonyms	N-Desethylchloroquine-d4; 4-Amino-1-(4-(diethylamino-d4)-1-methylbutylamino)quinoline; 7-Chloro-4-((4-(diethylamino-d4)-1-methylbutyl)amino)quinoline; Chloroquine Desethyl-d4; Chloroquine Metabolite-d4; Bisdesethylchloroquine-d4 precursor; CDCQ-d4; D4-Labeled Desethyl Chloroquine
EINECS	Contact for details

Quality Control

Our Desethyl Chloroquine-D4 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity, chemical purity, and isotopic enrichment. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage at -20°C under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.