Description

n-Desmethyl Clomipramine-D3 Hydrochloride is a deuterated internal standard of high analytical importance. This compound is specifically designed for use in quantitative mass spectrometry, providing superior accuracy and reliability in method development and validation. It is an essential reference material for pharmaceutical research, forensic toxicology, and clinical diagnostic laboratories requiring precise measurement of clomipramine and its metabolites.

Application

• LC-MS/MS Internal Standard: Primary application for the accurate quantification of clomipramine and its desmethyl metabolite in complex biological matrices.
• Pharmaceutical R&D: Used in pharmacokinetic and pharmacodynamic studies, metabolism investigations, and bioanalytical method development.
• Forensic & Clinical Toxicology: Critical for the reliable detection and measurement of tricyclic antidepressants in serum, plasma, or urine for diagnostic and legal purposes.
• Metabolite Profiling: Enables detailed study of clomipramine's metabolic pathways and the identification of specific metabolites.
• Quality Control in Reference Material Production: Serves as a certified reference material (CRM) for calibrating analytical systems and ensuring data integrity across laboratories.

Basic Information

Product Name	n-Desmethyl Clomipramine-D3 Hydrochloride
CAS No.	1189971-04-7
Molecular Formula	C₁₈H₁₈D₃ClN₂•HCl
Molecular Weight	349.72 g/mol
Synonyms	Desmethylclomipramine-d3 Hydrochloride; Norclomipramine-d3 Hydrochloride; 3-(3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine-d3 Hydrochloride; Clomipramine Metabolite-d3 HCl; Didesmethylclomipramine-d3 Hydrochloride (if applicable); Deuterated Norclomipramine HCl; Internal Standard for Clomipramine-d3; [2H3]-Desmethylclomipramine Hydrochloride
EINECS	Contact for details

Quality Control

Our n-Desmethyl Clomipramine-D3 Hydrochloride is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm chemical identity, isotopic purity (>98 atom % D), and chemical purity (typically ≥95%). Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.