Description

4-Boc-1-(1,4-Benzodioxan-2-Ylcarbonyl)Piperazine-D8 is a deuterated derivative of a key piperazine-based building block, where eight hydrogen atoms are replaced with deuterium, a stable isotope. This deuteration is critical for enhancing metabolic stability and traceability in pharmacokinetic and drug metabolism studies, providing invaluable data for drug development. This high-purity labeled compound is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions engaged in advanced medicinal chemistry and analytical method development.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical quantitative reference standard in bioanalytical assays for accurate measurement of the non-deuterated parent drug in biological matrices.
• Metabolic Stability and DMPK Studies: Used in Absorption, Distribution, Metabolism, and Excretion (ADME) research to investigate the metabolic pathways and stability of pharmaceutical candidates.
• Isotope Dilution Mass Spectrometry: Employed in high-precision analytical techniques to improve accuracy and minimize matrix effects in complex sample analysis.
• Pharmaceutical Intermediate Synthesis: Acts as a specialized building block for synthesizing deuterated drug candidates, potentially leading to improved pharmacokinetic profiles.
• Mechanistic Reaction Studies: Utilized as a tracer in chemical and enzymatic reaction studies to elucidate detailed mechanisms.

Basic Information

Product Name	4-Boc-1-(1,4-Benzodioxan-2-Ylcarbonyl)Piperazine-D8
CAS No.	1189968-99-7
Molecular Formula	C19H18D8N2O5
Molecular Weight	~378.48 g/mol
Synonyms	1,4-Benzodioxan-2-carboxylic acid, 1-(1,1-dimethylethoxy)carbonyl-4-piperazinyl ester-d8; 1-Boc-4-(1,4-benzodioxane-2-carbonyl)piperazine-d8; tert-Butyl 4-(2,3-dihydro-1,4-benzodioxine-2-carbonyl)piperazine-1-carboxylate-d8; 4-(1,4-Benzodioxan-2-carbonyl)-N-Boc-piperazine-d8; Piperazine-d8, 1-[(1,1-dimethylethoxy)carbonyl]-4-(2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl)-
EINECS	Contact for details

Quality Control

Every batch of our 4-Boc-1-(1,4-Benzodioxan-2-Ylcarbonyl)Piperazine-D8 is synthesized and purified under controlled conditions to meet the stringent requirements of research and development. We employ advanced analytical techniques including NMR (¹H, ¹³C) and High-Performance Liquid Chromatography (HPLC) to confirm chemical identity, isotopic purity (D-enrichment), and chemical purity. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment to ensure traceability and compliance with your quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.