Description

Metaxalone D6 is a deuterated internal standard of the centrally acting skeletal muscle relaxant, Metaxalone, specifically designed for high-precision analytical applications. This stable isotope-labeled compound is essential for ensuring accurate quantification and method validation in sophisticated mass spectrometry workflows. It is a critical reagent for pharmaceutical research and development laboratories, clinical testing facilities, and forensic toxicology units requiring the highest standards of analytical reliability.

Application

• Quantitative Bioanalysis: Serves as an internal standard for the precise LC-MS/MS quantification of Metaxalone in complex biological matrices such as plasma, serum, and urine.
• Pharmacokinetic & Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Forensic & Clinical Toxicology: Used in confirmatory testing and accurate measurement of Metaxalone levels for therapeutic drug monitoring or intoxication cases.
• Method Development & Validation: Critical for establishing and validating robust, sensitive, and specific analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Drug Impurity Profiling: Aids in the identification and quantification of potential deuterated impurities or metabolites in drug substance and product analysis.
• Reference Material for GLP/GMP Laboratories: Provides a traceable and consistent standard essential for maintaining data integrity in regulated laboratory environments.

Basic Information

Product Name	Metaxalone D6
CAS No.	1189944-95-3
Molecular Formula	C12H9D6NO3
Molecular Weight	227.28 g/mol
Synonyms	Metaxalone-d6; 5-[(3,5-Dimethylphenoxy)methyl]-2-oxazolidinone-d6; 3,5-Dimethylphenol, 2-oxo-3-oxazolidinylmethyl ether-d6; Skelaxin-d6 (deuterated); Metaxalone (hexadeuterated); [2H6]-Metaxalone
EINECS	Contact for details

Quality Control

Our Metaxalone D6 is manufactured under strict quality systems to ensure the highest isotopic purity and chemical integrity required for analytical standards. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided, detailing isotopic enrichment (typically ≥98 atom % D), chemical purity (≥95%), and analytical results. We support compliance with GLP and ISO 17025 standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.