Description

Methyl 4’-[[2-n-Propyl-4-Methyl-6-(1-Methylbenzimidazol-2-Yl)-Benzimidazol-1-Yl]Methyl]Biphenyl-2-Carboxylate-D3 is a deuterated derivative of a benzimidazole-based compound, serving as a critical stable isotope-labeled internal standard for analytical chemistry. This high-purity material is essential for ensuring the accuracy and reliability of quantitative analysis, particularly in pharmacokinetic and metabolic studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers working on drug development and bioanalytical method validation. The compound, identified by CAS No. 1189944-53-3, is supplied under stringent quality control to meet the exacting demands of modern trace-level analysis.

Application

• Internal Standard for LC-MS/MS: Used as a deuterium-labeled internal standard for the precise quantification of its non-deuterated counterpart in complex biological matrices like plasma, serum, and urine.
• Pharmaceutical R&D: Critical for conducting accurate Absorption, Distribution, Metabolism, and Excretion (ADME) studies and pharmacokinetic (PK) profiling during drug development.
• Bioanalytical Method Development: Enables the development and validation of robust, sensitive, and specific analytical methods in compliance with FDA and ICH guidelines.
• Metabolite Identification & Profiling: Aids in distinguishing drug-derived metabolites from endogenous compounds in mass spectrometry-based assays.
• Clinical Trial Support: Provides essential analytical reliability for measuring drug concentrations in samples from preclinical and clinical trials.
• Quality Control in API Manufacturing: Can be utilized in analytical laboratories for process control and impurity profiling of active pharmaceutical ingredients (APIs).

Basic Information

Item	Details
Product Name	Methyl 4’-[[2-n-Propyl-4-Methyl-6-(1-Methylbenzimidazol-2-Yl)-Benzimidazol-1-Yl]Methyl]Biphenyl-2-Carboxylate-D3
CAS No.	1189944-53-3
Molecular Formula	C33H30D3N4O2
Molecular Weight	~ 524.66 g/mol (for deuterated form)
Synonyms	Telmisartan-d3; Telmisartan Methyl Ester-d3; 4'-[[2-n-Propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazol-1-yl]methyl]biphenyl-2-carboxylic acid methyl ester-d3; BIBR 277-d3; BIBR-277-d3; Methyl 4'-[(2-n-propyl-4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-1H-benzimidazol-1-yl)methyl]biphenyl-2-carboxylate-d3
EINECS	Contact for details

Quality Control

Our deuterated internal standards are manufactured and tested under a strict quality management system. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and Mass Spectrometry to confirm isotopic purity, chemical purity, and structural identity. A comprehensive Certificate of Analysis (COA) is provided, detailing the results for isotopic enrichment (typically >98% D), chemical purity (typically >98%), and other critical parameters. Our quality commitment ensures the material is suitable for GLP/GMP-compliant analytical work.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.