Description

Acetildenafil-D8 is a deuterated analog of acetildenafil, a selective phosphodiesterase type 5 (PDE5) inhibitor, specifically labeled with eight deuterium atoms. This stable isotope-labeled compound is of critical importance for use as an internal standard in quantitative analytical methods, ensuring the highest accuracy and reliability in mass spectrometry-based assays. It is primarily required by pharmaceutical research laboratories, forensic toxicology units, and analytical service providers engaged in drug metabolism and pharmacokinetics (DMPK) studies, anti-doping analysis, and the development of precise bioanalytical methods.

Application

• Internal Standard for LC-MS/MS: Essential for the accurate quantification of acetildenafil and related analogs in complex biological matrices such as plasma, serum, and urine.
• Pharmaceutical Research & Development: Used in drug metabolism studies (DMPK) to track the pharmacokinetic profile of non-labeled compounds.
• Forensic and Anti-Doping Analysis: Supports the identification and confirmation of PDE5 inhibitors and designer analogs in forensic toxicology and sports doping control.
• Reference Standard for Method Validation: Serves as a certified reference material for developing, validating, and calibrating analytical instruments and procedures.
• Quality Control in Manufacturing: Employed in the QC laboratories of pharmaceutical manufacturers to ensure product purity and consistency.
• Academic and Clinical Research: Facilitates investigative studies on the biochemical pathways and effects of PDE5 inhibition.

Basic Information

Product Name	Acetildenafil-D8
CAS No.	1189944-10-2
Molecular Formula	C23H24D8N6O4S
Molecular Weight	476.62 g/mol
Synonyms	Acetildenafil-d8; 2-[2-Ethoxy-5-(4-ethylpiperazin-1-yl-d8)sulfonylphenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4(3H)-one; Deuterated Acetildenafil; Acetildenafil (D8); PDE5 Inhibitor D8 Internal Standard
EINECS	Contact for details

Quality Control

Our Acetildenafil-D8 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR and Mass Spectrometry for structural confirmation and isotopic purity, and HPLC for chemical purity assessment. We provide comprehensive Certificates of Analysis (COA) detailing batch-specific results for chemical purity, isotopic enrichment, and solvent residues, ensuring full traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.