Description

Pirenzepine-D8 is a deuterated analog of the selective M1 muscarinic receptor antagonist pirenzepine, specifically labeled with eight deuterium atoms. This stable isotope-labeled compound is an essential internal standard for the precise and accurate quantification of pirenzepine in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Internal Standard for Bioanalysis: Serves as a critical internal standard in the quantitative LC-MS/MS analysis of pirenzepine in plasma, serum, and other biological fluids.
• Pharmacokinetic & Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Method Development & Validation: Used as a reference material to develop, optimize, and validate robust and compliant bioanalytical methods.
• Drug Impurity Profiling: Aids in the identification and quantification of deuterated impurities or metabolites in drug substance and product analysis.
• Stable Isotope Dilution Mass Spectrometry: Employed in high-precision quantitative assays where isotope dilution is necessary to correct for matrix effects and instrument variability.

Basic Information

Product Name	Pirenzepine-D8
CAS No.	1189944-02-2
Molecular Formula	C19H13D8N5O2
Molecular Weight	351.44 g/mol
Synonyms	Pirenzepine-d8; 11-[(4-Methyl-1-piperazinyl)acetyl]-5H-dibenzo[b,e][1,4]diazepin-d8; 5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one-d8; Deuterated Pirenzepine; Pirenzepine (hexadeutero); LS-519-d8; Gastrozepin-d8
EINECS	Contact for details

Quality Control

Our Pirenzepine-D8 is manufactured under strict quality control protocols to ensure the high chemical purity and isotopic enrichment required for sensitive mass spectrometry applications. Each batch is characterized by NMR, HPLC, and MS to confirm identity, chemical purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.