Description

Baclofen-D4 CAS NO 1189938-30-4 is a deuterated analog of the pharmaceutical agent Baclofen, a γ-aminobutyric acid (GABA) derivative used as a muscle relaxant and antispastic agent. This stable isotope-labeled compound is essential for use as an internal standard in quantitative analytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities focused on drug development, bioanalysis, and quality control.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative reference standard in Liquid Chromatography-Tandem Mass Spectrometry for the analysis of Baclofen in biological matrices (plasma, serum, urine).
• Pharmacokinetic & Metabolism Research: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) studies in preclinical and clinical research.
• Bioanalytical Method Development & Validation: Used to develop, optimize, and validate robust analytical methods compliant with FDA, EMA, and ICH guidelines.
• Drug Impurity Profiling & Stability Testing: Assists in the identification and quantification of degradation products and related substances in drug substances and products.
• Forensic & Clinical Toxicology: Supports accurate quantification of Baclofen in forensic analysis and therapeutic drug monitoring (TDM) programs.
• Isotope Dilution Mass Spectrometry (IDMS): Serves as the ideal spike for high-precision IDMS, the gold standard for definitive quantitative analysis.

Basic Information

Product Name	Baclofen-D4
CAS No.	1189938-30-4
Molecular Formula	C10H8D4ClNO2
Molecular Weight	217.68 g/mol (for C10H8D4ClNO2)
Synonyms	4-Amino-3-(4-chlorophenyl)-D4-butyric acid; β-(4-Chlorophenyl)-GABA-D4; Baclofen (phenyl-D4); Lioresal-D4; (RS)-Baclofen-D4; 3-(4-Chlorophenyl)-4-aminobutyric acid-D4; Baclofen (ring-D4); Baclofen-d4 (Major)
EINECS	Contact for details

Quality Control

Our Baclofen-D4 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is fully characterized and undergoes rigorous testing, including HPLC for chemical purity, NMR and MS for structural and isotopic confirmation, and residual solvent analysis. Comprehensive Certificates of Analysis (COA) detailing batch-specific results are provided and traceable to primary reference standards. Our quality commitment supports compliance with cGMP and ISO 9001 standards for research materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant and under inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure and isotopic pattern
Purity (HPLC)	≥98.0% (Chemical Purity)
Isotopic Purity (D-content)	≥98.0 atom % D
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.