Description

α-(4-Bromophenyl)-α-[2-(Dimethyl-D6-Amino)Ethyl]-3-Pyridinemethanol is a deuterated fine chemical intermediate of significant importance in advanced pharmaceutical research and development. Its core value lies in enabling the creation of deuterium-labeled drug candidates, which can offer improved metabolic stability and pharmacokinetic profiles. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries working on novel therapeutic agents.

Application

• Deuterated Active Pharmaceutical Ingredient (API) Synthesis: A key building block for incorporating deuterium atoms into the molecular structure of new drug candidates.
• Metabolic Stability Studies: Used to create isotopically labeled analogs for in vitro and in vivo ADME (Absorption, Distribution, Metabolism, Excretion) profiling.
• Internal Standards for Bioanalysis: Serves as a critical standard in LC-MS/MS methods for the accurate quantification of non-deuterated parent compounds in biological matrices.
• Mechanism of Action (MOA) Research: Facilitates tracer studies to elucidate biochemical pathways and drug-target interactions.
• Process Chemistry & Scale-Up: Employed in the development and optimization of synthetic routes for deuterated pharmaceuticals.
• Neurological & Psychiatric Drug Discovery: Potential intermediate for compounds targeting receptors where the dimethylaminoethyl and pyridine motifs are pharmacologically relevant.

Basic Information

Product Name	α-(4-Bromophenyl)-α-[2-(Dimethyl-D6-Amino)Ethyl]-3-Pyridinemethanol
CAS No.	1189936-97-7
Molecular Formula	C16H18BrD6NO
Molecular Weight	Contact for details
Synonyms	3-Pyridinemethanol, α-(4-bromophenyl)-α-[2-(dimethyl-d6-amino)ethyl]-; α-(4-Bromophenyl)-α-[2-(dimethylamino-d6)ethyl]-3-pyridinemethanol; (4-Bromophenyl)2-(dimethyl-d6-amino)ethylmethanol; Deutetrabenazine-d6 Intermediate; Deuterated Tetrabenazine Analog; D6-Dimethylaminoethyl Pyridine Methanol Derivative
EINECS	Contact for details

Quality Control

Our α-(4-Bromophenyl)-α-[2-(Dimethyl-D6-Amino)Ethyl]-3-Pyridinemethanol is manufactured under strict quality systems suitable for research and development use. Each batch undergoes rigorous analytical testing, including NMR (1H, 13C), HPLC, and MS, to confirm identity, chemical purity, and isotopic enrichment (D6). A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (D6)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.