Description

Desmethyl Sibutramine-D6, Hydrochloride is a high-purity, deuterium-labeled internal standard critical for precise analytical quantification. This compound is essential for ensuring accuracy and reliability in sophisticated mass spectrometry-based analyses, particularly in regulated environments. It is primarily utilized by pharmaceutical research laboratories, contract research organizations (CROs), and forensic testing facilities engaged in method development and validation.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative reference standard in the analysis of sibutramine and its metabolites in complex biological matrices.
• Pharmaceutical R&D: Supports pharmacokinetic, pharmacodynamic, and bioequivalence studies for drug development programs.
• Forensic Toxicology: Enables accurate detection and quantification of sibutramine in anti-doping controls and forensic investigations.
• Metabolite Studies: Facilitates research into the metabolic pathways and clearance of sibutramine-related compounds.
• Method Validation: Critical for developing and validating compliant analytical methods according to FDA, EMA, and other regulatory guidelines.
• Quality Control Labs: Employed in GMP/GLP environments for the quality testing of pharmaceutical products and raw materials.

Basic Information

Product Name	Desmethyl Sibutramine-D6, Hydrochloride
CAS No.	1189935-32-7
Molecular Formula	C16H20D6ClN
Molecular Weight	Contact for details
Synonyms	1-(4-Chlorophenyl)-N,N-dimethyl-α-(2-methylpropyl)-cyclobutanemethanamine-D6 Hydrochloride; N-Desmethyl Sibutramine-D6 HCl; Sibutramine Desmethyl Metabolite-D6 Hydrochloride; Deuterated Desmethyl Sibutramine HCl; Internal Standard for Sibutramine-D6
EINECS	Contact for details

Quality Control

Every batch of Desmethyl Sibutramine-D6, Hydrochloride is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with the high-purity standards required for analytical reference materials. A detailed Certificate of Analysis (COA), providing batch-specific data on purity, isotopic enrichment, and impurities, is supplied with each product to support your regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D6)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.