Description

Adefovir-D4, Diethyl Ester is a deuterated derivative of the antiviral prodrug Adefovir Dipivoxil, specifically designed for use as a high-purity internal standard in analytical chemistry. This stable isotope-labeled compound is critical for ensuring the accuracy and reliability of quantitative mass spectrometry analyses in pharmaceutical research and development. It is primarily utilized by analytical laboratories and pharmaceutical companies engaged in method development, pharmacokinetic studies, and quality control for antiviral medications.

Application

• Internal Standard for LC-MS/MS: Essential for the precise quantification of Adefovir and its metabolites in biological matrices (plasma, serum, urine) during pharmacokinetic and bioequivalence studies.
• Pharmaceutical R&D: Used in method development and validation for the analysis of antiviral drug formulations and stability testing.
• Metabolite Tracing: Facilitates the study of drug metabolism and disposition pathways due to its deuterium labeling, which provides a distinct mass signature.
• Reference Material: Serves as a certified reference standard to calibrate analytical instruments and ensure data integrity in regulatory submissions.
• Doping Control Analysis: Potential application in forensic and sports anti-doping laboratories for the detection of prohibited antiviral substances.

Basic Information

Product Name	Adefovir-D4, Diethyl Ester
CAS No.	1189929-36-9
Molecular Formula	C12H15D4N5O4P
Molecular Weight	331.30 g/mol (for monoisotopic mass)
Synonyms	9-[2-[Bis[(pivaloyloxy)methoxy]phosphinyl]methoxy]ethyl]adenine-d4; PMEA bis(pivaloyloxymethyl) ester-d4; Adefovir Dipivoxil-d4; GS 840-d4; Bis(POM)PMEA-d4; Deuterated Adefovir Dipivoxil; [[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]phosphonic acid diethyl ester-d4
EINECS	Contact for details

Quality Control

Every batch of Adefovir-D4, Diethyl Ester is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure exceptional isotopic purity and chemical identity. Our quality assurance protocols are designed to meet the stringent requirements of analytical reference standard applications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for assay, isotopic enrichment, and purity by HPLC and NMR.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. The compound is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (by MS)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.