Description

Rhein-13C4 CAS NO 1189928-10-6 is a stable isotope-labeled analog of Rhein, where four carbon atoms are replaced with the Carbon-13 (13C) isotope. This compound is essential as an internal standard in quantitative mass spectrometry, enabling highly accurate and reliable analysis of the native compound in complex biological and chemical matrices. It is primarily required by researchers and quality control laboratories in the pharmaceutical, biotechnology, and analytical chemistry sectors for drug metabolism studies, pharmacokinetic research, and method validation.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of Rhein in bioanalytical assays, ensuring data integrity in pharmacokinetic and bioavailability studies.
• Drug Metabolism and Disposition (DMPK) Research: Used as a tracer to study the metabolic pathways, absorption, distribution, and excretion of Rhein in preclinical and clinical research.
• Method Development and Validation: Serves as a reference material for developing and validating robust analytical methods in compliance with regulatory guidelines (e.g., FDA, ICH).
• Biomarker Analysis: Facilitates accurate measurement of Rhein as a potential biomarker in physiological or pathological studies.
• Pharmaceutical Quality Control: Ensures batch-to-batch consistency and purity assessment of Rhein-containing pharmaceutical ingredients and finished products.
• Stable Isotope Labeling Studies: Used in mechanistic studies to trace the fate of specific atoms within the Rhein molecule during chemical or biological reactions.

Basic Information

Product Name	Rhein-13C4
CAS No.	1189928-10-6
Molecular Formula	C1513C4H8O6
Molecular Weight	~290.22 g/mol (exact mass varies with isotopic enrichment)
Synonyms	4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid-13C4; Cassic acid-13C4; Monorhein-13C4; 1,8-Dihydroxy-3-carboxyanthraquinone-13C4; Rhubarb yellow-13C4; Rheic acid-13C4; [13C4]-Rhein
EINECS	Contact for details

Quality Control

Every batch of Rhein-13C4 is manufactured and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) that detail isotopic purity (enrichment), chemical purity, and identity confirmation. Our quality protocols are designed to meet the stringent requirements of analytical reference standard applications, ensuring reliability for your most critical research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (13C)	≥ 99 atom % 13C
Isotopic Enrichment	≥ 99% on four labeled positions
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.