Description

1-[(4-Chlorophenyl)Phenylmethyl]-Piperazine-D8 is a deuterated analog of a key piperazine derivative, where eight hydrogen atoms are replaced with deuterium, a stable, non-radioactive isotope. This deuteration is critical for creating internal standards used in advanced analytical techniques, ensuring unparalleled accuracy and reliability in quantitative measurements. It is an essential material for researchers and quality control laboratories in the pharmaceutical, agrochemical, and forensic science industries who require precise metabolic and pharmacokinetic studies.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, isotopically labeled internal standard in Liquid Chromatography-Tandem Mass Spectrometry for the accurate quantification of its non-deuterated counterpart in complex biological matrices.
• Pharmaceutical Metabolism Studies: Enables precise tracking and analysis of drug metabolism, absorption, distribution, and excretion (ADME) in preclinical and clinical research.
• Forensic and Clinical Toxicology: Used in method development and validation for the sensitive and specific detection of target analytes in forensic investigations and clinical toxicology screenings.
• Agrochemical Research: Facilitates the study of environmental fate, degradation pathways, and residue analysis of related chemical agents.
• Biomedical Research: Supports proteomics and metabolomics research where precise quantification of specific biomarkers is required.
• Method Development and Validation: Essential for developing, optimizing, and validating robust analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).

Basic Information

Product Name	1-[(4-Chlorophenyl)Phenylmethyl]-Piperazine-D8
CAS No.	1189925-23-2
Molecular Formula	C17H11D8ClN2
Molecular Weight	~289.85 g/mol
Synonyms	1-[(4-Chlorophenyl)(phenyl)methyl]piperazine-d8; 1-(4-Chlorobenzhydryl)piperazine-d8; Norchlorcyclizine-d8; 1-[(p-Chloro-α-phenylbenzyl)]piperazine-d8; 4-[(4-Chlorophenyl)phenylmethyl]piperazine-d8; NSC 169865-d8; Deuterated Chlorcyclizine Impurity/Intermediate
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity. Each batch is characterized using advanced analytical techniques including NMR (for deuterium incorporation), HPLC, and Mass Spectrometry. A comprehensive Certificate of Analysis (COA) detailing isotopic purity, chemical purity, and analytical data is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.