Description

Rac Guaifenesin-D3 is a deuterated isotopologue of the widely used expectorant and mucolytic agent, guaifenesin. This compound is of significant value for use as an internal standard in quantitative analytical methods, particularly in mass spectrometry, ensuring precise and reliable measurement of its non-deuterated counterpart. It is primarily utilized by pharmaceutical research and development laboratories, analytical testing facilities, and manufacturers of reference standards to enhance the accuracy of pharmacokinetic, bioequivalence, and quality control studies.

Application

• Internal Standard for LC-MS/MS Analysis: Critical for the accurate quantification of guaifenesin in complex biological matrices such as plasma, serum, and urine.
• Pharmaceutical R&D: Employed in drug metabolism and pharmacokinetics (DMPK) studies to track the absorption, distribution, metabolism, and excretion (ADME) of guaifenesin.
• Bioanalytical Method Development: Serves as a stable, non-interfering reference compound to validate and calibrate analytical assays.
• Quality Control & Assurance: Used in the pharmaceutical manufacturing process to ensure batch-to-batch consistency and purity of guaifenesin-based drug products.
• Reference Standard Production: A key material for certified reference material (CRM) manufacturers supplying the analytical market.

Basic Information

Product Name	Rac Guaifenesin-D3
CAS No.	1189924-85-3
Molecular Formula	C10H11D3O4
Molecular Weight	201.24 g/mol
Synonyms	Guaifenesin-d3 (Racemic); 3-(2-Methoxyphenoxy)-1,2-propanediol-1,1,2-d3; DL-Guaifenesin-d3; Guaiphenesin-d3; Glyceryl guaiacolate-d3; Rac 1,2-Propanediol, 3-(2-methoxyphenoxy)-, 1,1,2-d3; (±)-Guaifenesin-d3
EINECS	Contact for details

Quality Control

Our Rac Guaifenesin-D3 is manufactured under strict quality control protocols to ensure high chemical and isotopic purity suitable for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR and HPLC/MS, to confirm identity and isotopic enrichment. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and deuterium content is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.