Description

Triamterene-D5 is a deuterium-labeled analog of the potassium-sparing diuretic Triamterene, specifically designed for use as an internal standard in analytical chemistry. This high-purity stable isotope-labeled compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry (MS) and liquid chromatography-mass spectrometry (LC-MS/MS) analyses. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, clinical research, and forensic toxicology sectors who require precise measurement of Triamterene in complex biological matrices.

Application

• Internal Standard for Quantitative Bioanalysis: Primary use as an isotopic internal standard in LC-MS/MS methods for the accurate quantification of Triamterene in plasma, serum, and urine.
• Pharmaceutical Research & Development: Supports pharmacokinetic (PK), pharmacodynamic (PD), and metabolism studies during drug development.
• Clinical and Forensic Toxicology: Enables precise monitoring of Triamterene levels for therapeutic drug monitoring (TDM) or forensic investigations.
• Method Development and Validation: Serves as a critical reference material for developing, validating, and ensuring the robustness of analytical methods according to GLP/GCP guidelines.
• Metabolite Identification and Tracing: Aids in the identification and study of Triamterene metabolites using advanced mass spectrometry techniques.

Basic Information

Product Name	Triamterene-D5
CAS No.	1189922-23-3
Molecular Formula	C12H6D5N7
Molecular Weight	260.30 g/mol
Synonyms	2,4,7-Triamino-6-phenylpteridine-D5; 6-Phenyl-2,4,7-pteridinetriamine-D5; Triamterene (phenyl-D5); Triamterene-d5; Deuterated Triamterene; [D5]-Triamterene; 2,4,7-Triamino-6-(pentadeuteriophenyl)pteridine
EINECS	Contact for details

Quality Control

Every batch of Triamterene-D5 is manufactured and analyzed under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Our products undergo rigorous quality testing, including NMR and MS for isotopic enrichment verification and HPLC for chemical purity assessment, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	Yellow to yellow-brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.