Description

10,11-Dihydro-10-Hydroxycarbamazepine-D3 is a high-purity, deuterium-labeled internal standard critical for modern analytical chemistry. This compound is specifically designed for use in quantitative bioanalysis, providing unmatched accuracy and reliability in mass spectrometry-based assays. It is an essential tool for pharmaceutical researchers, clinical laboratories, and contract research organizations (CROs) engaged in drug metabolism and pharmacokinetic (DMPK) studies, therapeutic drug monitoring, and forensic toxicology.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable, isotopically labeled internal standard for the precise quantification of carbamazepine and its metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmaceutical R&D: Enables accurate pharmacokinetic profiling and bioequivalence studies for carbamazepine-based drug formulations during development stages.
• Clinical Toxicology & TDM: Supports reliable therapeutic drug monitoring (TDM) for patients undergoing treatment with antiepileptic drugs, ensuring optimal dosing and minimizing side effects.
• Forensic Analysis: Used in forensic laboratories for the definitive identification and quantification of carbamazepine in post-mortem and legal casework samples.
• Metabolite Studies: Facilitates research into the metabolic pathways and clearance mechanisms of carbamazepine in vivo.
• Method Development & Validation: Serves as a critical component in developing, optimizing, and validating robust, regulatory-compliant analytical methods (e.g., following FDA, EMA guidelines).

Basic Information

Product Name	10,11-Dihydro-10-Hydroxycarbamazepine-D3
CAS No.	1189917-36-9
Molecular Formula	C₁₅H₁₀D₃N₂O₂
Molecular Weight	256.30 g/mol
Synonyms	10,11-Dihydro-10-hydroxycarbamazepine-d3; 10-Hydroxy-10,11-dihydrocarbamazepine-d3; 10-OH-Carbamazepine-d3; 10-Hydroxy Carbamazepine-d3; 10,11-Dihydro-10-hydroxy-5H-dibenzo[b,f]azepine-5-carboxamide-d3; 10-OH-CBZ-d3; CBZ-10-OH-d3; Deuterated 10,11-Dihydro-10-Hydroxycarbamazepine
EINECS	Contact for details

Quality Control

Every batch of 10,11-Dihydro-10-Hydroxycarbamazepine-D3 is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We guarantee high chemical and isotopic purity to ensure optimal performance as an internal standard. Certificates of Analysis (COA) are provided with each shipment, detailing results from NMR, HPLC, and mass spectrometry. Our quality commitment supports compliance with GMP/GLP principles for research and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 99.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.