Description

o-Desmethyl Indomethacin-D4 is a high-purity, deuterium-labeled internal standard critical for advanced analytical chemistry. This compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses in pharmaceutical research and development. It is primarily used by scientists and quality control laboratories in the pharmaceutical, contract research organization (CRO), and academic sectors for precise pharmacokinetic and metabolic studies of indomethacin and related compounds.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound for the accurate quantification of indomethacin and its metabolites in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical studies.
• Bioanalytical Method Development and Validation: Used to develop, optimize, and validate robust high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) methods.
• Pharmacological Research: Facilitates detailed metabolic pathway analysis and the study of enzyme kinetics related to the non-steroidal anti-inflammatory drug (NSAID) indomethacin.
• Forensic and Anti-Doping Analysis: Supports highly specific and confirmatory testing in forensic toxicology and sports anti-doping controls.
• Quality Control in Pharmaceutical Manufacturing: Assays for trace-level impurities and degradation products during drug substance and drug product manufacturing.

Basic Information

Product Name	o-Desmethyl Indomethacin-D4
CAS No.	1189916-55-9
Molecular Formula	C18H11D4ClNO4
Molecular Weight	~ 361.79 g/mol
Synonyms	2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic-2,2,3,3-d4 acid; 5-Desmethyl Indomethacin-D4; Indomethacin Impurity D (Deuterated); 5-O-Desmethyl Indomethacin-d4; 5-Hydroxy Indomethacin-D4; Deuterated Indomethacin Metabolite; [2,2,3,3-2H4]-2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic Acid
EINECS	Contact for details

Quality Control

Every batch of o-Desmethyl Indomethacin-D4 is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to support your regulatory submissions, including Certificates of Analysis (COA) detailing purity, isotopic enrichment, and impurity profiles. Our standards are suitable for use in GLP (Good Laboratory Practice) and GMP (Good Manufacturing Practice) environments, ensuring reliable and reproducible results in your critical assays.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.