Description

N,n-Didesmethyl Trimebutine-D5 Hydrochloride is a high-purity, deuterated isotopologue of a key pharmaceutical intermediate. This compound is specifically designed for use as an internal standard in quantitative mass spectrometry, ensuring superior analytical accuracy and reliability. It is an essential material for pharmaceutical R&D, quality control laboratories, and contract research organizations (CROs) engaged in the development and bioanalysis of trimebutine and related compounds.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable, isotopically labeled internal standard for the precise quantification of trimebutine and its metabolites in biological matrices (plasma, serum, urine).
• Pharmaceutical R&D: Critical for pharmacokinetic (PK), pharmacodynamic (PD), and bioequivalence studies during drug development stages.
• Metabolite Identification & Profiling: Aids in the structural elucidation and tracking of metabolic pathways in preclinical and clinical research.
• Quality Control & Method Validation: Used in analytical method development and validation to ensure accuracy, precision, and compliance with regulatory guidelines (FDA, EMA).
• Reference Standard: Serves as a certified reference material for calibrating analytical instruments and verifying assay specificity.

Basic Information

Product Name	N,n-Didesmethyl Trimebutine-D5 Hydrochloride
CAS No.	1189893-33-1
Molecular Formula	C22H30D5NO4 • HCl
Molecular Weight	Contact for details
Synonyms	Trimebutine-d5 (N,N-didesmethyl); 2-(Dimethylamino)-2-phenylbutyl 3,4,5-trimethoxybenzoate-d5 Hydrochloride; 3,4,5-Trimethoxybenzoic Acid 2-(Dimethylamino)-2-phenylbutyl Ester-d5 Hydrochloride; Deuterated Trimebutine Internal Standard; N,N-Didesmethyltrimebutine-d5 HCl; M-1-d5 Metabolite of Trimebutine; (RS)-2-Dimethylamino-1-phenylbutan-1-yl 3,4,5-trimethoxybenzoate-d5 hydrochloride
EINECS	Contact for details

Quality Control

Our N,n-Didesmethyl Trimebutine-D5 Hydrochloride is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch undergoes comprehensive testing, including HPLC for chemical purity, NMR and MS for structural confirmation and deuterium incorporation. A detailed Certificate of Analysis (COA) is provided, listing batch-specific results for identity, assay, isotopic purity, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D5)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.