Description

Clomipramine-D6 Hydrochloride CAS NO 1189882-28-7 is a deuterium-labeled internal standard of the tricyclic antidepressant clomipramine, essential for ensuring accuracy and reliability in quantitative analytical methods. This high-purity, isotopically labeled compound is critical for researchers and quality control laboratories requiring precise measurements in complex matrices. It is primarily used in pharmaceutical research, forensic toxicology, and clinical diagnostics for method development and validation.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative reference in liquid chromatography-tandem mass spectrometry for the accurate analysis of clomipramine and its metabolites in biological samples.
• Pharmacokinetic and Metabolism Studies: Enables precise tracking and quantification of drug absorption, distribution, metabolism, and excretion (ADME) in research settings.
• Forensic and Clinical Toxicology: Supports reliable quantification of clomipramine in blood, plasma, or urine for overdose cases, therapeutic drug monitoring, and post-mortem investigations.
• Pharmaceutical Quality Control (QC): Serves as a critical component in the validation of analytical methods for drug substance and finished product testing.
• Bioanalytical Method Development: Provides a stable isotopic marker to optimize extraction efficiency, chromatography, and mass spectrometric detection parameters.
• Reference Material for Certified Standards: Used in the preparation and certification of calibration standards and quality control samples.

Basic Information

Product Name	Clomipramine-D6 Hydrochloride
CAS No.	1189882-28-7
Molecular Formula	C19H17D6Cl2N2•HCl
Molecular Weight	~369.75 g/mol
Synonyms	3-(3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine-D6 Hydrochloride; Clomipramine-d6 HCl; Deuterated Clomipramine Hydrochloride; Anafranil-d6 Hydrochloride; 3-(3-Chloro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine-d6 Hydrochloride
EINECS	Contact for details

Quality Control

Our Clomipramine-D6 Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR and Mass Spectrometry for structural confirmation and isotopic purity, and HPLC for chemical purity assessment. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and all relevant specifications is provided with every shipment to ensure traceability and compliance with your research or quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (Mass Spec)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium Enrichment)	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.