Description

Cyclobenzaprine-D3 n-Oxide is a deuterated analog of the cyclobenzaprine metabolite, specifically designed for use as an internal standard in analytical chemistry. This high-purity reference material is critical for ensuring accurate quantification and method validation in complex biological matrices. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and forensic toxicology units engaged in advanced pharmacokinetic studies and drug metabolism research.

Application

• Quantitative Bioanalysis: Serves as a stable isotope-labeled internal standard for the precise LC-MS/MS quantification of cyclobenzaprine and its metabolites in plasma, serum, and urine.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in clinical and pre-clinical trials.
• Forensic Toxicology: Used in confirmatory testing and method development for the detection of cyclobenzaprine in forensic and workplace drug testing programs.
• Metabolite Identification & Profiling: Aids in the structural elucidation and relative quantification of drug metabolites during biotransformation studies.
• Method Development & Validation: Essential for establishing and validating robust, reproducible, and GLP-compliant analytical methods in regulatory submissions.
• Quality Control in Reference Material Production: Acts as a critical calibrant for ensuring the accuracy and traceability of certified reference materials (CRMs).

Basic Information

Product Name	Cyclobenzaprine-D3 n-Oxide
CAS No.	1189877-07-3
Molecular Formula	C20H18D3NO
Molecular Weight	293.41 g/mol
Synonyms	Cyclobenzaprine-d3 N-Oxide; 5-(3-Dibenzocycloheptatrienylidene)-N,N-dimethyl-1-propanamine-d3 N-Oxide; Cyclobenzaprine D3 Oxide; Cyclobenzaprine N-Oxide-d3; Deuterated Cyclobenzaprine N-Oxide; Cyclobenzaprine Metabolite-d3; Amrix-d3 N-Oxide; Fexmid-d3 N-Oxide
EINECS	Contact for details

Quality Control

Every batch of Cyclobenzaprine-D3 n-Oxide is manufactured and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing purity, isotopic enrichment, and impurity profiles, ensuring compliance with the rigorous standards required for analytical reference standards. Our quality protocols are designed to support GLP and GMP environments where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This product is hygroscopic (moisture-sensitive); ensure the original container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 99.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.