Description

7-Chloro-5-(2-Fluorophenyl)-2-Methylamino-3H-1,4-Benzodiazepine-13C1 is a stable isotope-labeled analog of a 1,4-benzodiazepine derivative, where a carbon-13 atom is incorporated at a specific position. This compound is of critical importance for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is primarily needed by pharmaceutical research and development laboratories, forensic toxicology units, and clinical diagnostic facilities for method development, pharmacokinetic studies, and metabolite identification.

Application

• Internal Standard for LC-MS/MS: Essential for the precise quantification of its non-labeled counterpart and related metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmaceutical R&D: Used in drug metabolism and pharmacokinetics (DMPK) studies to track absorption, distribution, metabolism, and excretion (ADME) profiles.
• Forensic Analysis: Provides definitive identification and accurate concentration measurement in forensic toxicology screenings for benzodiazepine-class substances.
• Clinical Research: Enables reliable measurement of drug concentrations in patient samples for therapeutic drug monitoring and clinical trial bioanalysis.
• Reference Material: Serves as a high-purity certified reference material (CRM) for calibrating analytical instruments and validating testing methods.
• Metabolite Studies: Aids in the structural elucidation and quantification of drug metabolites formed in vitro or in vivo.

Basic Information

Product Name	7-Chloro-5-(2-Fluorophenyl)-2-Methylamino-3H-1,4-Benzodiazepine-13C1
CAS No.	1189874-88-1
Molecular Formula	C16H12ClFN3 (with one 13C atom)
Molecular Weight	~299.74 g/mol (exact mass varies with isotopic enrichment)
Synonyms	7-Chloro-5-(2-fluorophenyl)-2-(methylamino)-3H-1,4-benzodiazepine-13C1; 2'-Fluoro-Deschloro-N-methylclonazepam-13C1; 2'-Fluoro-Deschloro-N-methylclonazepam (13C Labeled); 13C-Labeled Benzodiazepine Derivative; 2'-Fluoro-Deschloro-N-methylclonazepam-13C; Stable Isotope-Labeled 1,4-Benzodiazepine; [13C]-2'-Fluoro-Deschloro-N-methylclonazepam
EINECS	Contact for details

Quality Control

Every batch of 7-Chloro-5-(2-Fluorophenyl)-2-Methylamino-3H-1,4-Benzodiazepine-13C1 is produced and analyzed under strict quality management protocols. We guarantee high chemical purity and isotopic enrichment, with comprehensive testing including HPLC for chemical purity and mass spectrometry for isotopic abundance verification. Certificates of Analysis (COA) detailing batch-specific results are provided with each shipment to ensure full traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant in the storage area.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.