Description

Temazepam-13C,D3 CAS NO 1189871-79-1 is a stable isotope-labeled analog of the benzodiazepine drug Temazepam, specifically enriched with carbon-13 and deuterium. This high-purity reference standard is critical for ensuring accurate and reliable quantitative analysis in complex biological matrices. It is an essential tool for pharmaceutical research and development, clinical laboratories, and forensic toxicology departments requiring definitive analytical results.

Application

• Internal Standard for LC-MS/MS and GC-MS: Primary application as a quantitative internal standard in mass spectrometry-based bioanalysis for drug metabolism and pharmacokinetic (DMPK) studies.
• Pharmaceutical R&D: Used in the development and validation of analytical methods for Temazepam and its metabolites.
• Forensic and Clinical Toxicology: Enables precise measurement of Temazepam levels in blood, urine, and other specimens for medico-legal and diagnostic purposes.
• Metabolite Identification Studies: Aids in tracking and identifying drug metabolites using isotope pattern recognition techniques.
• Quality Control in Reference Material Production: Serves as a calibrant for ensuring the accuracy of unlabeled Temazepam reference standards.
• Regulatory Compliance Testing: Supports method development for compliance with FDA, EMA, and other regulatory agency requirements for bioanalytical method validation.

Basic Information

Product Name	Temazepam-13C,D3
CAS No.	1189871-79-1
Molecular Formula	C16H10D3 13C N2O2
Molecular Weight	~ 304.3 g/mol
Synonyms	7-Chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one-13C,D3; (13C,D3)-Temazepam; Temazepam (phenyl-13C6, 3,4,5-D3); Temazepam-13C6,D3; 3-Hydroxydiazepam-13C,D3; 3-OH-Diazepam-13C,D3; Oxazepam methyl ether-13C,D3; We 941-13C,D3; Euhypnos-13C,D3; Normison-13C,D3; Restoril-13C,D3
EINECS	Contact for details

Quality Control

Our Temazepam-13C,D3 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results from advanced analytical techniques including NMR, HPLC, and MS. We ensure compliance with relevant standards for high-purity reference materials, and custom synthesis and purification to meet specific client requirements are available.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or CoA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (by MS)	≥ 99 atom % 13C; ≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.