Description

Tianeptine-D12 is a stable isotope-labeled analog of the tricyclic antidepressant agent tianeptine, specifically deuterated at twelve positions. This high-purity reference standard is essential for ensuring analytical accuracy and reliability in quantitative mass spectrometry. It is primarily used by research institutions, pharmaceutical developers, and analytical laboratories engaged in pharmacokinetic studies, metabolic profiling, and forensic toxicology. The compound serves as a critical internal standard for precise quantification of tianeptine in complex biological matrices.

Application

• As an internal standard for the accurate quantification of tianeptine in biological samples (e.g., plasma, urine, tissue) using LC-MS/MS or GC-MS.
• For conducting pharmacokinetic and drug metabolism studies to understand the absorption, distribution, metabolism, and excretion (ADME) profile of tianeptine.
• In forensic and clinical toxicology laboratories for the definitive identification and measurement of tianeptine in casework and compliance testing.
• Use in pharmaceutical research and development for method development, validation, and quality control of analytical assays.
• Supporting regulatory submissions to agencies like the FDA and EMA by providing validated data from studies using a certified reference material.
• Application in academic research investigating the neuropharmacological mechanisms and biochemical pathways of tianeptine and related compounds.

Basic Information

Product Name	Tianeptine-D12
CAS No.	1189870-26-5
Molecular Formula	C21H13D12ClN2O4S
Molecular Weight	~445.0 g/mol
Synonyms	7-[(3-Chloro-6-methyl-5,5-dideutero-6,8-dideutero-5H-dibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,S-dioxide-d10; Tianeptine-d12; Deuterated Tianeptine; Tianeptine (D12); Stablon-d12; Coaxil-d12; Tatinol-d12; DA 6886-d12
EINECS	Contact for details

Quality Control

Every batch of Tianeptine-D12 is manufactured and analyzed under strict quality management systems. The product undergoes rigorous testing to ensure exceptional isotopic purity and chemical identity, meeting the stringent requirements for certified reference standards. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for assay, isotopic enrichment, and purity by HPLC and NMR. Our quality commitment supports compliance with GMP/GLP principles for research and analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant and under inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.