Description

4-Methoxy Propranolol-D7 is a deuterium-labeled analog of the β-blocker propranolol, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity stable isotope-labeled compound is critical for ensuring accuracy and reliability in mass spectrometry-based analyses, particularly in pharmacokinetic and metabolism studies. It is an essential tool for pharmaceutical researchers, contract research organizations (CROs), and analytical laboratories requiring precise quantification of propranolol and its metabolites in complex biological matrices.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard in Liquid Chromatography-Tandem Mass Spectrometry for bioanalytical method development and validation.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in studies to track the absorption, distribution, metabolism, and excretion (ADME) of propranolol.
• Clinical Research: Enables precise measurement of propranolol concentrations in plasma, serum, and other biological fluids during clinical trials.
• Forensic Toxicology: Supports accurate quantification in forensic analyses for cases involving propranolol.
• Pharmaceutical Quality Control: Can be utilized in impurity profiling and assay development for propranolol-containing drug products.
• Isotope Dilution Mass Spectrometry (IDMS): Serves as the labeled spike in IDMS, the gold-standard technique for achieving high metrological accuracy.

Basic Information

Product Name	4-Methoxy Propranolol-D7
CAS No.	1189868-02-7
Molecular Formula	C16H14D7NO3
Molecular Weight	~273.38 g/mol
Synonyms	1-(Isopropylamino)-3-(4-methoxy-1-naphthyloxy)-2-propanol-D7; Propranolol D7 (4-Methoxy); 4-Methoxypropranolol-d7; Deuterated 4-Methoxy Propranolol; [D7]-4-Methoxypropranolol; 4-Methoxypropranolol Internal Standard; 4-Methoxy-1-naphthoxypropranolol-D7
EINECS	Contact for details

Quality Control

Every batch of 4-Methoxy Propranolol-D7 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, confirmed by advanced spectroscopic and chromatographic techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific results for identity, purity, isotopic enrichment, and solvent content. Our quality commitment ensures data integrity for your most critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. Keep the container in a dry, well-ventilated place. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.