Description

n-Des[2-(2-Hydroxyethoxy)Ethyl] Quetiapine-D8 is a deuterated analog of a key metabolite of the antipsychotic drug quetiapine. This compound is of critical importance for use as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolism studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug development and therapeutic drug monitoring.

Application

• Bioanalytical Internal Standard: Essential for Liquid Chromatography-Mass Spectrometry (LC-MS/MS) quantification of quetiapine and its metabolites in biological matrices (plasma, serum, urine).
• Pharmacokinetic (PK) Studies: Used to accurately determine drug absorption, distribution, metabolism, and excretion (ADME) profiles during clinical trials.
• Metabolite Profiling & Identification: Aids in the structural elucidation and quantification of drug metabolites in in vitro and in vivo studies.
• Therapeutic Drug Monitoring (TDM): Supports the development and validation of robust assays for monitoring patient drug levels to optimize dosing and efficacy.
• Regulatory Submission Support: Provides the high-quality reference material needed for generating data compliant with FDA, EMA, and ICH guidelines.
• Stability-Indicating Methods: Employed in forced degradation studies and stability testing of pharmaceutical formulations.

Basic Information

Product Name	n-Des[2-(2-Hydroxyethoxy)Ethyl] Quetiapine-D8
CAS No.	1189866-35-0
Molecular Formula	C19H13D8N3O2S
Molecular Weight	Contact for details
Synonyms	Deuterated Quetiapine Metabolite; Quetiapine D8 Metabolite; Norquetiapine-D8; 11-Deuterio-4-(2-(2-hydroxyethoxy)ethyl)-1-thia-4,9-diazacyclopenta[b]naphthalene-5-one-d7; 11-Hydroxyquetiapine-D8 (related metabolite); 7-Hydroxyquetiapine-D8 (related metabolite); N-Desalkyl Quetiapine-D8; Internal Standard for Quetiapine LC-MS
EINECS	Contact for details

Quality Control

Every batch of our n-Des[2-(2-Hydroxyethoxy)Ethyl] Quetiapine-D8 is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive characterization using NMR, HRMS, and HPLC. Certificates of Analysis (COA) detailing purity, isotopic enrichment (D8), and chromatographic data are provided with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D8)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.