Description

1-[4-Hydroxy-2-[1,1,2,3,3-Pentadeuterio-2-Hydroxy-3-(Propylamino)Propoxy]Phenyl]-3-Phenylpropan-1-One:Hydrochloride is a deuterated chemical compound of significant interest in advanced pharmaceutical research and development. This molecule serves as a critical isotopically labeled intermediate or reference standard for metabolic and pharmacokinetic studies. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and analytical laboratories engaged in the development of novel therapeutics, particularly for precise bioanalytical method validation and drug metabolism investigations.

Application

• Pharmaceutical Reference Standard: Used as a certified internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and LC-MS/MS for the quantitative analysis of its non-deuterated counterpart in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential for conducting mass balance studies, metabolite identification, and tracing the absorption, distribution, metabolism, and excretion (ADME) pathways of drug candidates.
• Bioanalytical Method Development: Provides a stable, isotopically labeled analog to improve assay accuracy, precision, and reliability by correcting for matrix effects and instrument variability.
• Isotope Dilution Mass Spectrometry (IDMS): Acts as a high-purity spike in IDMS techniques for the absolute quantification of target analytes in complex samples.
• Clinical Research: Employed in human clinical trials to support pharmacokinetic profiling and ensure regulatory compliance for data integrity.
• Chemical Synthesis Research: Serves as a specialized building block or tracer in the synthesis of deuterated drug molecules for enhanced metabolic stability or as a research tool.

Basic Information

Item	Details
Product Name	1-[4-Hydroxy-2-[1,1,2,3,3-Pentadeuterio-2-Hydroxy-3-(Propylamino)Propoxy]Phenyl]-3-Phenylpropan-1-One:Hydrochloride
CAS No.	1189863-32-8
Molecular Formula	C21H22D5ClNO4
Molecular Weight	Contact for details
Synonyms	Deuterated Carvedilol Metabolite Standard; 1-[4-Hydroxy-2-[1,1,2,3,3-Pentadeuterio-2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-1-propanone hydrochloride; Pentadeuterio-carvedilol related compound hydrochloride; 4-(2-Hydroxy-3-((1,1,2,3,3-pentadeuterio-2-hydroxypropyl)(propyl)amino)propoxy)-9H-carbazol-9-yl hydrochloride (common misassignment); BM 14190 deuterated analog HCl; (±)-1-(Carbazol-4-yloxy)-3-[[2-(1,1,2,3,3-pentadeuterio-2-methoxyphenoxy)ethyl]amino]-2-propanol hydrochloride; Deuterated adrenergic blocker intermediate.
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality management systems to ensure the highest standards of isotopic purity and chemical integrity. Each batch undergoes comprehensive analysis using advanced techniques including NMR (¹H, ²H), High-Resolution Mass Spectrometry (HRMS), and HPLC to confirm identity, chemical purity, and deuterium incorporation. Certificates of Analysis (COA) detailing all specifications are provided and traceable to primary reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuterium Incorporation (²H NMR/MS)	≥ 95 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.