Description

8-Hydroxy Loxapine-D3 is a deuterium-labeled analog of a key metabolite of the antipsychotic agent loxapine. This stable isotope-labeled compound is essential for precise quantitative analysis in pharmacokinetic and metabolic studies, ensuring high accuracy and reliability in research data. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers specializing in drug development and bioanalytical method validation.

Application

• Internal Standard for LC-MS/MS: Serves as a critical internal standard for the accurate quantification of 8-hydroxy loxapine and related metabolites in biological matrices (e.g., plasma, serum, urine) using liquid chromatography-tandem mass spectrometry.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables detailed investigation of the absorption, distribution, metabolism, and excretion (ADME) profile of loxapine in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Used as a reference standard to develop, optimize, and validate robust, sensitive, and specific analytical methods compliant with FDA and ICH guidelines.
• Clinical Trial Support: Facilitates reliable therapeutic drug monitoring and pharmacokinetic profiling during clinical trials of loxapine and its formulations.
• Forensic and Toxicology Analysis: Aids in the precise identification and quantification of loxapine metabolites in forensic toxicology casework.
• Reference Material for Quality Control: Acts as a high-purity certified reference material for calibrating instruments and ensuring the quality of analytical results in testing laboratories.

Basic Information

Product Name	8-Hydroxy Loxapine-D3
CAS No.	1189863-10-2
Molecular Formula	C18H15D3ClN2O
Molecular Weight	328.82 g/mol
Synonyms	8-Hydroxyloxapine-d3; 2-Chloro-11-(4-methyl-1-piperazinyl)dibenzo[b,f][1,4]oxazepin-8-ol-d3; Loxapine Metabolite 8-OH-D3; 8-OH-Loxapine-d3; Deuterated 8-Hydroxy Loxapine; 8-Hydroxy Loxapine (D3); Loxapine-8-ol-d3
EINECS	Contact for details

Quality Control

Our 8-Hydroxy Loxapine-D3 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and isotopic enrichment meet the stringent requirements for use as an internal standard. Comprehensive Certificates of Analysis (COA) detailing all analytical results are provided to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to keep the material under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium Content)	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.