Description

n-Propionyl Mesalazine-D5 is a deuterium-labeled derivative of mesalazine, a key pharmaceutical compound. This stable isotope-labeled analog is specifically designed for use as an internal standard in quantitative bioanalytical methods, ensuring high accuracy and reliability in mass spectrometry-based analyses. It is an essential tool for researchers and quality control laboratories in the pharmaceutical and contract research organization (CRO) sectors, particularly for drug metabolism and pharmacokinetics (DMPK) studies, clinical trial analysis, and ensuring regulatory compliance for mesalazine-based therapeutics.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard in Liquid Chromatography-Tandem Mass Spectrometry for the accurate measurement of mesalazine and its metabolites in biological matrices.
• Pharmaceutical R&D: Critical for drug metabolism and pharmacokinetics (DMPK) studies during the development of new mesalazine formulations or prodrugs.
• Clinical Research: Used in the analysis of patient samples from clinical trials to monitor drug exposure, bioavailability, and adherence.
• Bioanalytical Method Development & Validation: Enables the development, optimization, and validation of robust, sensitive, and specific analytical methods compliant with FDA, EMA, and ICH guidelines.
• Forensic & Doping Analysis: Supports precise quantification in specialized testing environments where high analytical certainty is required.
• Metabolite Identification & Profiling: Aids in the structural elucidation and quantification of mesalazine metabolites in complex biological systems.

Basic Information

Product Name	n-Propionyl Mesalazine-D5
CAS No.	1189861-06-0
Molecular Formula	C10D5H6NO4
Molecular Weight	Approx. 221.21 g/mol
Synonyms	5-Amino-2-hydroxybenzoic acid 3-(propionyl-d5); Deuterated n-Propionyl Mesalazine; Mesalazine-d5 Propionate; 5-ASA-d5 Propionate; 5-Aminosalicylic Acid-d5 Propionyl Ester; Deuterium Labeled Mesalamine Propionate; Internal Standard for Mesalazine LC-MS; [D5]-n-Propionyl Mesalazine
EINECS	Contact for details

Quality Control

Every batch of n-Propionyl Mesalazine-D5 is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, with comprehensive testing performed using advanced techniques including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic enrichment, and confirming the absence of significant unlabeled impurities. Our quality commitment supports compliance with the rigorous standards required for pharmaceutical research and bioanalytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.