Description

n-Desmethyl Pirenzepine-D8 is a high-purity, deuterium-labeled internal standard critical for advanced analytical applications. This compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses, particularly in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities requiring precise and stable isotopic labels for method development and validation.

Application

• Quantitative Bioanalysis: Serves as a stable isotope-labeled internal standard for the accurate LC-MS/MS quantification of pirenzepine and its metabolites in biological matrices like plasma, serum, and urine.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Metabolite Identification & Profiling: Aids in the structural elucidation and quantification of desmethyl metabolites of pirenzepine, facilitating a deeper understanding of its metabolic pathways.
• Method Development & Validation: Used as a critical reference material to develop, optimize, and validate robust, GLP-compliant analytical methods in regulated environments.
• Doping Control & Forensic Analysis: Applied in specialized testing protocols for the detection and confirmation of specific substances in forensic and anti-doping laboratories.

Basic Information

Product Name	n-Desmethyl Pirenzepine-D8
CAS No.	1189860-05-6
Molecular Formula	C₁₉H₁₃D₈N₅O₂
Molecular Weight	~359.45 g/mol
Synonyms	Pirenzepine-d8 Desmethyl Metabolite; 11-[(4-Methyl-1-piperazinyl-d8)acetyl]-5H-dibenzo[b,e][1,4]diazepin-6-one; Desmethylpirenzepine-d8; Norpirenzepine-d8; Pirenzepine N-Desmethyl-d8; Deuterated n-Desmethyl Pirenzepine; Pirenzepine Metabolite M1-d8; LS-198860
EINECS	Contact for details

Quality Control

Every batch of n-Desmethyl Pirenzepine-D8 is manufactured under strict quality control protocols to ensure exceptional isotopic purity and chemical integrity. Our products undergo rigorous testing, including HPLC, NMR, and mass spectrometry, to confirm identity, chemical purity, and isotopic enrichment. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool environment. This material is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere or with desiccant to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98.0 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.